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보유 기술 및 설비 홈 > 회사소개 > 보유 기술 및 설비 
Medicinal Chemistry
The medicinal chemists are responsible for the creation of new chemical entities that will eventually become Leadgene's new medicines. Working closely with other deciplines, medicinal chemists design and synthesize optimal molecules using expertise in organic chemistry. Each new molecule is tested in biological assays to establish the structure/activity relationships that guide subsequent stages of the refinement process.
 
Combinatorial Chemistry
In order to increase potency, obtain desired pharmacological and metabolic properties, reduce activity against other undesirable targets and minimize drug interactions, medicinal chemists synthesize related structures by using traditional medicinal chemistry and/or combinatorial chemistry.
 
Chemical Process Development
The process research chemists design practical, efficient, environmentally favorable way of chemical syntheses for Leadgene’s drug substances.
 
Chiral Catalyst
Chirotechnology has received considerable attention for the production of optically active compounds. Especially, the development of chiral catalysts is a major concern, since they can offer environmentally responsible and atom economical solution for the production of active pharmaceutical ingredients. Leadgene has successfully performed the Korean government research project developing chiral catalysts.
 
Facilities
High Resolution 400MHz NMR
HPLC & MPLC
Quest 210 : Argonaut Technologies
Biotage : Flash collector
 
Recent Publications
1. E. S. Jeong, J. W. Lee, R. K. Chang, S. W. Cho, Z. O. Lee, S. H. Yun, M. X. Xiang, H. Yoon, “ Improved Process for the Preparation of 2-Acetyloxy-4-trifluoromethylbenzoic acid”, KR10-0025971.

2. J. W. Lee, E. S. Jeong, R. K. Chang, S. W. Cho, Z. O. Lee, S. H. Yun, M. X. Xiang, H. Yoon, “ Improved Process for the Preparation of Carbazole Derivatives”, KR10-0064511.

3. J. Kim, K. I. Kim, J. W. Lee, E. S. Jeong, S. H. Yun, J. Y. Park, M. X. Xiang, H. Yoon, “Improved Process for the Preparation of 3-[2-{4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl}ethyl]-6,7,8,9-tetrahydro-
2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one and its intermediates”, KR10-0457496.

4. J. W. Lee, E. S. Jeong, R. K. Chang, S. W. Cho, Z. O. Lee, S. H. Yun, M. X. Xiang, H. Yoon, “Improved Process for the Preparation of 1-Methyl-4-piperidyl ester of a-Phenyl-a-propoxyphenylacetic acid and its hydrochloride salt”, KR10-0483317.

5. T.H. Ryu, H. Yoon, “Improved processes for the preparation of 2-(2-aminoethyl)-1-methylpyrrolidine”, KR10-0696187.

6. Y.-S. Lee, J.M. Jeong, Y.J. Kim, Y.S. Chang, H.J. Lee, M. Son, J.W. Lee, H. Yoon, W.J. Kang, D.S. Lee, J.-K. Chung, M.C. Lee, Y.-G. Suh, “Development of acetylated HDD kit for preparation 188Re-HDD/lipiodol”, Appl. Radiat. Isot. 2007, 65, 64.
 
 
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